X0306 4 2022-06-01 0 0001785530 Werewolf Therapeutics, Inc. HOWL 0001654430 Morrison Briggs C/O WEREWOLF THERAPEUTICS, INC. 200 TALCOTT AVENUE, 2ND FLOOR WATERTOWN MA 02472 1 0 0 0 Stock Option (right to buy) 3.43 2022-06-01 4 A 0 11600 0.00 A 2032-05-31 Common Stock 11600 11600 D The option was granted on June 1, 2022. The shares underlying the option vest in full on the earlier of the first anniversary of the grant date and the next annual meeting of stockholders following the grant date, subject to the reporting person's continued service as a director. Exhibit Index: 24.1 Power of Attorney /s/ Jonathan Owen, Attorney-in-fact 2022-06-03