X0306 4 2021-04-30 0 0001785530 Werewolf Therapeutics, Inc. HOWL 0001792061 DiRocco Derek C/O WEREWOLF THERAPEUTICS, INC. 1030 MASSACHUSETTS AVENUE, SUITE 210 CAMBRIDGE MA 02138 1 0 0 0 Stock Option (right to buy) 16.00 2021-04-30 4 A 0 23200 0.00 A 2031-04-29 Common Stock 23200 23200 D The option was granted on April 30, 2021. The shares underlying the option vest over three years, with one-third of the shares vesting on the first anniversary of the date of grant and the remaining shares vesting in equal monthly installments thereafter. Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received from the option, which will offset advisory fees owed by the Fund and the Nexus Fund II to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and underlying common stock. /s/ Reid Leonard, Attorney-in-fact 2021-05-04