X0306 4 2023-02-28 0 0001785345 Landos Biopharma, Inc. LABP 0001944447 Cataldi Fabio C/O LANDOS BIOPHARMA, INC. PO BOX 11239 BLACKSBURG VA 24062 0 1 0 0 Chief Medical Officer Employee Stock Option (right to buy) 0.37 2023-02-28 4 A 0 184500 0.00 A 2033-02-27 Common Stock 184500 184500 D Restricted Stock Unit 2023-02-28 4 A 0 276750 0.00 A 2033-02-27 Common Stock 276750 276750 D 1/4th of the shares initially subject to the option shall vest on the one (1) year anniversary of the date of grant (such anniversary being the "Anniversary Date") and 1/48th of the shares initially subject to the option shall vest on each monthly anniversary of the Anniversary Date thereafter, subject to the Reporting Person's continuous service with the Issuer on each such date. Each restricted stock unit represents the right to receive one share of Landos Biopharma, Inc., Inc. common stock. The Restricted Stock Unit ("RSU") shall vest as to 66 2/3% of the shares underlying the RSU on the second anniversary of the date of grant and shall vest as to 33 1/3% of the shares underlying the RSU on the third anniversary of the date of grant, subject to the Reporting Person's continuous service with the Issuer on each such date. /S/ Gregory Oakes, Attorney-in-Fact 2023-03-02