X0206 3 2021-02-03 0 0001785345 Landos Biopharma, Inc. LABP 0001843703 Hontecillas Raquel C/O LANDOS BIOPHARMA, INC. 1800 KRAFT DRIVE, SUITE 216 BLACKSBURG VA 24060 0 1 0 0 Chief Scientific Officer Common Stock 182490 I By Trust Stock Option (right to buy) 1.86 2030-10-19 Common Stock 182490 D Reflects a 1.8249-for-1 stock split of the Issuer's common stock effected on January 29, 2021. Securities are held by the Raquel Hontecillas-Magarzo Revocable Trust Agreement dated April 9, 2018, as amended (the "Trust"). The Reporting Person is the sole trustee of the Trust and the beneficiaries are the Reporting Person's immediate family members. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of her pecuniary interest therein. The shares of common stock underlying this option will vest and become exercisable in 24 equal monthly installments beginning on February 1, 2021, subject to the Reporting Person's continuous service with the Issuer on each such date. Exhibit List - Exhibit 24 - Power of Attorney /s/ Eric W. Blanchard, Attorney-in-Fact 2021-02-03