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Stock-based compensation - Additional information (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2019
Jan. 01, 2023
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Total stock-based compensation expense $ 1,971 $ 4,118    
Share-based Payment Award, Options, Exercises in Period, Intrinsic Value $ 0 $ 1,300    
Weighted average fair value of options to purchase common stock granted $ 0.90 $ 7.19    
Unrecognized compensation cost $ 2,000      
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition 3 years 2 months 12 days      
Two Thousand Twenty One Employee Stock Purchase Plan [Member]        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Shares Available For Future Grants 791,251      
Shares available for future grants       402,548
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum 1.00%      
Two Thousand Twenty Two Inducement Plan [Member]        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Shares Available For Future Grants 1,000,000      
Lesser number of shares 1,000,000      
General and Administrative Expense        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Total stock-based compensation expense $ 1,333 $ 1,573    
General and Administrative Expense | Former Chief Executive Officer [Member]        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Total stock-based compensation expense   $ 300    
The2019 Plan [Member]        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Shares Available For Future Grants     6,921,233  
Lesser number of shares     1,000,000  
Shares available for future grants       1,824,900
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum     5.00%