Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (28,836)	$ (25,565)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	3,551	2,512
Net (accretion) amortization on available-for-sale securities	(1,040)	118
Accretion of final payment fee on term loan	87	121
Amortization of debt issuance costs	132	75
Loss on extinguishment of term loan facility	1,208
Noncash operating lease expense	41
Depreciation	14	18
Changes in operating assets and liabilities:
Prepaid and other current assets	(4,599)	1,942
Other assets		(72)
Accounts payable	4,225	(2,422)
Accrued expenses	(4,827)	(1,215)
Operating lease liability	(41)
Net cash used in operating activities	(30,085)	(24,344)
Cash flows from investing activities:
Proceeds from sales and maturities of available-for-sale securities	37,880	36,179
Purchases of available-for-sale securities	(33,774)	(9,401)
Purchases of property and equipment		(6)
Net cash (used in) provided by investing activities	4,106	26,772
Cash flows from financing activities:
Proceeds from issuance of common stock in public offering, net of issuance costs	296,817
Proceeds from term loan facility, net of issuance costs	24,363
Proceeds from issuance of common stock in at-the-market public offering, net of issuance costs	13,422
Proceeds from issuance of common stock upon exercise of warrants	8,960
Proceeds from issuance of common stock upon exercise of stock options	185	29
Payment of withholding taxes related to restricted stock units	(693)
Payment of term loan facility, including final payment	(21,400)
Net cash provided by financing activities	321,654	29
Net change in cash and cash equivalents, and restricted cash	295,675	2,457
Cash and cash equivalents, and restricted cash at beginning of period	55,255	52,457
Cash and cash equivalents, and restricted cash at end of period	350,930	54,914
Components of cash and cash equivalents, and restricted cash:
Cash and cash equivalents	350,930	54,889
Restricted cash		25
Total cash and cash equivalents, and restricted cash	350,930	54,914
Supplemental disclosures of cash information:
Cash paid for interest	542	$ 169
Cash paid for operating leases	47
Supplemental disclosures of noncash information:
Issuance of common stock warrants in connection with term loan	$ 482