X0306 4 2023-02-17 0 0001785173 89bio, Inc. ETNB 0001792062 Le-Nguyen Quoc C/O 89BIO, INC. 142 SANSOME STREET, 2ND FLOOR SAN FRANCISCO CA 94104 0 1 0 0 See Remarks Common Stock 2023-02-17 4 F 0 2140 13.97 D 91179 D Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the release of 5,775 restricted stock units on February 17, 2023. Chief Technical Operations Officer and Head of Quality /s/ Ryan A. Murr, as attorney-in-fact for Quoc Le-Nguyen 2023-02-22