X0306 4 2022-02-17 0 0001785173 89bio, Inc. ETNB 0001792062 Le-Nguyen Quoc C/O 89BIO, INC. 142 SANSOME STREET, 2ND FLOOR SAN FRANCISCO CA 94104 0 1 0 0 See Remarks Common Stock 2022-02-17 4 A 0 17500 0.00 A 27500 D Common Stock 2022-02-17 4 A 0 5000 0.00 A 32500 D Stock Option (Right to Buy) 4.44 2022-02-17 4 A 0 70000 0.00 A 2032-02-16 Common Stock 70000 70000 D Represents restricted stock units ("RSUs") that vest with respect to one-third of the underlying shares on February 17, 2023, with the remaining two-thirds vesting in equal semi-annual installments over the following two years, subject to the Reporting Person's continued service to the Issuer. Represents RSUs that vest in equal installments on each of August 1, 2022, February 1, 2023 and August 1, 2023. This option represents a right to purchase a total of 70,000 shares of the Issuer's Common Stock, one quarter of which will vest on February 17, 2023, with the remaining three quarters vesting in equal quarterly installments over the following three years, subject to the Reporting Person's continued service to the Issuer. Chief Technical Operations Officer and Head of Quality /s/ Ryan A. Murr, as attorney-in-fact for Quoc Le-Nguyen 2022-02-22