X0306 4 2022-02-17 0 0001785173 89bio, Inc. ETNB 0001423327 PALEKAR ROHAN C/O 89BIO, INC. 142 SANSOME STREET, 2ND FLOOR SAN FRANCISCO CA 94104 1 1 0 0 Chief Executive Officer Common Stock 2022-02-17 4 A 0 54200 0.00 A 100045 D Stock Option (Right to Buy) 4.44 2022-02-17 4 A 0 220000 0.00 A 2032-02-16 Common Stock 220000 220000 D Represents restricted stock units that vest with respect to one-third of the underlying shares on February 17, 2023, with the remaining two-thirds vesting in equal semi-annual installments over the following two years, subject to the Reporting Person's continued service to the Issuer. This option represents a right to purchase a total of 220,000 shares of the Issuer's Common Stock, one quarter of which will vest on February 17, 2023, with the remaining three quarters vesting in equal quarterly installments over the following three years, subject to the Reporting Person's continued service to the Issuer. /s/ Ryan A. Murr, as attorney-in-fact for Rohan Palekar 2022-02-22