X0306 4 2020-11-16 1 0001785173 89bio, Inc. ETNB 0001713663 Longitude Capital Partners III, LLC 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 0001674099 Longitude Venture Partners III, L.P. 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 0001431159 Tammenoms Bakker Juliet 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 0001253886 ENRIGHT PATRICK G 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 Common Stock 2020-11-16 4 J 0 850000 0.00 D 1750877 I See footnote Common Stock 2020-11-16 4 J 0 2973 0.00 A 2973 I See footnote Common Stock 2020-11-16 4 J 0 2080 0.00 A 2080 I See footnote Common Stock 2020-11-16 4 J 0 891 0.00 A 891 I See footnote Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners III, L.P. ("Longitude Venture III") to its general and limited partners. These shares are held directly by Longitude Venture III. Longitude Capital Partners III, LLC ("Longitude Capital III") is the general partner of Longitude Venture III and may be deemed to have voting, investment and dispositive power with respect to these securities. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of Longitude Capital III (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to these securities. Each of Longitude Capital III and the Managers disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members. These shares are held by a limited partnership (the "Partnership") of which the general partner is a trust (the "Trust"). Mr. Enright is the Trustee of the Trust and may be deemed to share voting, investment and dispositive power over the shares held by the Partnership. Each of the Trust and Mr. Enright disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Mr. Enright, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose. These shares are held by a trust. Ms. Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Ms. Bakker, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose. These shares are held directly by Ms. Bakker. Longitude Venture Partners III, L.P.; By /s/ Patrick G. Enright, Managing Member 2020-11-18 Longitude Capital Partners III, LLC; By /s/ Patrick G. Enright, Managing Member 2020-11-18 /s/ Juliet Tammenoms Bakker 2020-11-18 /s/ Patrick G. Enright 2020-11-18