X0306 4 2020-07-10 0 0001785173 89bio, Inc. ETNB 0001711080 Grunberg Gregory C/O 89BIO, INC. 142 SANSOME STREET, 2ND FLOOR SAN FRANCISCO CA 94104 1 0 1 0 Common Stock 2020-07-10 4 P 0 109090 27.50 A 2600877 I See footnote On July 10, 2020, Longitude Venture Partners III, L.P. ("Longitude Venture III") purchased 109,090 shares of the Issuer's common stock at a price of $27.50 per share in the Issuer's follow-on public offering. These shares are held directly by Longitude Venture III. Longitude Capital Partners III, LLC ("Longitude Capital III") is the general partner of Longitude Venture III. The Reporting Person is a member of Longitude Capital III and may be deemed to share voting, investment and dispositive power with respect to these securities. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interests therein. /s/ Gregory Grunberg 2020-07-14