X0306 4 2019-11-11 0 0001785173 89bio, Inc. ETNB 0001568077 Kariv Tomer 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 1 0 1 0 0001792890 Pontifax (Israel) V, L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 0001792893 Pontifax (Cayman) V, L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 0001792891 Pontifax (China) V, L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 0001792892 Pontifax 5 G.P. L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 0001726334 Pontifax Management 4 G.P. (2015) Ltd. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 0001793770 Pontifax Late Stage GP Ltd. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 0001793769 Pontifax Late Stage Fund L.P. 14 SHENKAR STREET, BEIT OFEK HERZLIYA PITUACH L3 L3 46140 ISRAEL 0 0 1 0 Common Stock 2019-11-11 4 P 0 250000 16.00 A 250000 I See footnotes Common Stock 2019-11-13 4 C 0 884671 A 1134671 I See footnotes Series A Preferred Stock 2019-11-13 4 C 0 5500001 0.00 D Common Stock 884671 0 I See footnotes On November 11, 2019, Pontifax (Israel) V, L.P. purchased 134,390 shares of the Issuer's common stock, Pontifax (Cayman) V, L.P. purchased 35,897 shares of the Issuer's common stock, Pontifax (China) V, L.P. (collectively, the "Pontifax Entities") purchased 52,213 shares of the Issuer's common stock and Pontifax Late Stage Fund L.P. ("Late Stage L.P.") purchased 27,500 shares of the Issuer's common stock at a price of $16.00 per share in the Issuer's initial public offering. The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date. Includes (a) 134,390 shares held by Pontifax (Israel) V, L.P., (b) 35,897 shares held by Pontifax (Cayman) V, L.P., (c) 52,213 shares held by Pontifax (China) V, L.P. and (d) 27,500 shares held by Late Stage L.P. Includes (a) 668,732 shares held by Pontifax (Israel) V, L.P., (b) 178,623 shares held by Pontifax (Cayman) V, L.P., (c) 259,816 shares held by Pontifax (China) V, L.P. and (d) 27,500 shares held by Late Stage L.P. Includes (a) 534,342 shares held by Pontifax (Israel) V, L.P., (b) 142,726 shares held by Pontifax (Cayman) V, L.P. and (c) 207,603 shares held by Pontifax (China) V, L.P. Pontifax 5 G.P. L.P. ("Pontifax 5 GP") is the general partner of each of the Pontifax Entities, and Pontifax Management 4 G.P. (2015) Ltd. ("Pontifax Management") is the general partner of Pontifax 5 GP. Mr. Tomer Kariv is one of two Managing Partners of Pontifax Management and, as a result, may be deemed to share voting and investment power with respect to the shares held by each of the Pontifax Entities. Mr. Kariv disclaims beneficial ownership of those shares held by the Pontifax Entities, except to the extent of his pecuniary interest therein. Late Stage L.P. invests side by side with Pontifax 5 GP pursuant to a Strategic Alliance Agreement with Pontifax 5 GP. Pontifax Late Stage GP Ltd. ("Late Stage GP") is the general partner of Late Stage L.P. (Continued from footnote 6) and the sole shareholder of Late Stage GP is Mr. Shlomo Karako. By virtue of the strategic relationship, each of Pontifax 5 GP, Pontifax Management, Ran Nussbaum, and Tomer Kariv may be deemed to share voting and dispositive power with respect to the shares held by Late Stage L.P. in a manner similar to the voting and investment power with respect to the shares held by each of the Pontifax Entities. In that context, Mr. Kariv disclaims beneficial ownership of such shares, and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise. /s/ Tomer Kariv 2019-11-13 Pontifax (Israel) V, L.P.; By /s/ Tomer Kariv, Chief Executive Officer 2019-11-13 Pontifax (Cayman) V, L.P.; By /s/ Tomer Kariv, Chief Executive Officer 2019-11-13 Pontifax (China) V, L.P.; By /s/ Tomer Kariv, Chief Executive Officer 2019-11-13 Pontifax 5 G.P. L.P.; By /s/ Tomer Kariv, Chief Executive Officer 2019-11-13 Pontifax Management 4 G.P. (2015) Ltd.; By /s/ Tomer Kariv, Chief Executive Officer 2019-11-13 Pontifax Late Stage GP Ltd.; By /s/ Tomer Kariv, Authorized Signatory 2019-11-13 Pontifax Late Stage Fund L.P.; By /s/ Tomer Kariv, Authorized Signatory 2019-11-13