X0206 3 2019-11-08 0 0001785173 89bio, Inc. ETNB 0001423327 PALEKAR ROHAN C/O 89BIO, INC. 535 MISSION STREET, 14TH FLOOR SAN FRANCISCO CA 94105 1 1 0 0 Chief Executive Officer Stock Option (Right to Buy) 1.93 2028-11-09 Common Stock 325231 D Stock Option (Right to Buy) 3.11 2029-07-30 Common Stock 132242 D This option represents a right to purchase a total of 325,231 shares of the Issuer's common stock, one quarter of which vested on July 16, 2019, with the remaining three quarters vesting in equal quarterly installments over the following three years. This option represents a right to purchase a total of 132,242 shares of the Issuer's common stock, one quarter of which will vest on July 23, 2020, with the remaining three quarters vesting in equal quarterly installments over the following three years. Exhibit 24 - Power of Attorney /s/ Ryan A. Murr, Attorney-in-Fact for Rohan Palekar 2019-11-08