X0306 4 2021-02-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001784038 Fink Eric C/O GLOBAL BLOOD THERAPEUTICS, INC. 181 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Human Resources Officer Common Stock 2021-02-01 5 A 0 E 322 42.60 A 322 D Common Stock 2021-02-01 4 M 0 3020 A 3342 D Common Stock 2021-02-01 4 F 0 947 49.49 D 2395 D Restricted Stock Units 2021-02-01 4 M 0 3020 0.00 D Common Stock 3020 18120 D Shares acquired pursuant to the Issuer's Amended and Restated 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c). Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. Represents number of shares of Issuer's Common Stock sold to satisfy the Reporting Person's tax obligations in connection with the vesting of 3,020 shares of Common Stock underlying the Reporting Person's RSUs. The shares of Common Stock underlying the RSUs vest in 8 equal semi-annual installments over 4 years from February 1, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Tricia Suvari, as Attorney-in-Fact 2021-02-03