X0306 4 2019-09-01 0 0001629137 Global Blood Therapeutics, Inc. GBT 0001784038 Fink Eric C/O GLOBAL BLOOD THERAPEUTICS, INC. 171 OYSTER POINT BLVD., SUITE 300 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Human Resources Officer Stock Option (Right to Buy) 45.98 2019-09-01 4 A 0 38000 0.00 A 2029-08-31 Common Stock 38000 38000 D Restricted Stock Units 2019-09-01 4 A 0 25000 0.00 A Common Stock 25000 25000 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's Common Stock. The shares of Common Stock underlying the option shall vest with respect to 1/4th of the shares on August 5, 2020 and thereafter 1/12th of the remaining underlying shares shall vest in equal quarterly installments over 3 years from August 5, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. This option is subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. The shares of Common Stock underlying the RSUs shall vest with respect to 1/4th of the shares on September 1, 2020 and thereafter 1/6th of the remaining underlying shares shall vest in semi-annual installments over 3 years from September 1, 2020, so long as the Reporting Person continues as an employee or other service provider of the Issuer through each vesting date. The RSUs are subject to accelerated vesting upon termination without cause or resignation for good reason after a change of control of the Issuer. /s/ Lesley Ann Calhoun, as Attorney-in-Fact 2019-09-04