Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Cash flows from operating activities:
Net loss	$ (129,766)	$ (127,499)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	2,866	4,108
Accretion of marketable securities	(2,409)	(3,897)
Non-cash interest expense related to loan payable	462	773
Loss on extinguishment of debt		1,090
Stock-based compensation	11,706	9,549
Changes in current assets and liabilities:
Prepaid expenses and other assets	(525)	(538)
Right-of-use assets and lease liabilities, net	2,909	1,881
Accounts payable	(3,011)	1,994
Accrued expense and other liabilities	(7,226)	4,532
Deferred revenue	(10,325)	(2,815)
Net cash used in operating activities	(135,319)	(110,822)
Cash flows from investing activities:
Purchases of property and equipment	(4,407)	(3,825)
Purchases of marketable securities	(87,471)	(241,445)
Proceeds from maturities of marketable securities	201,250	192,657
Net cash provided by (used in) investing activities	109,372	(52,613)
Cash flows from financing activities:
Repayment of loan payable, net		(17,144)
Proceeds from borrowings under loan agreement, net		32,457
Proceeds from issuance of common stock, net of offering costs		33,131
Proceeds from issuance of pre-funded warrants, net of offering costs		158,271
Issuance of common stock under employee stock purchase plan	264	333
Proceeds from exercise of stock options		1,717
Cash paid for debt issuance costs	(400)
Cash paid for financing costs	(200)
Net cash provided by (used in) financing activities	(336)	208,765
Net increase (decrease) in cash, cash equivalents and restricted cash	(26,283)	45,330
Cash, cash equivalents, and restricted cash - beginning of year	183,720	138,390
Cash, cash equivalents, and restricted cash - end of year	157,437	183,720
Summary of cash, cash equivalents and restricted cash reported within the consolidated balance sheets:
Cash and cash equivalents	152,406	178,689
Restricted cash	5,031	5,031
Total cash, cash equivalents, and restricted cash	157,437	183,720
Supplemental disclosure of cash flow information:
Cash paid for interest	2,307	2,881
Supplemental disclosure of non-cash investing and financing activities:
Debt issuance costs not yet paid		400
Financing costs not yet paid		200
Lease liability arising from obtaining right-of-use asset		6,133
Purchase of property and equipment in accounts payable and accrued liabilities	$ 7	84
Issuance of common stock upon note conversion		$ 14,750