Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Cash flows from operating activities:
Net loss	$ (127,499)	$ (89,218)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	4,108	5,361
Accretion of marketable securities	(3,897)	(1,072)
Non-cash interest expense related to loan payable	773	757
Loss on extinguishment of debt	1,090
Stock-based compensation	9,549	5,208
Changes in current assets and liabilities:
Prepaid expenses and other assets	(538)	985
Right-of-use assets and lease liabilities, net	1,881	935
Accounts payable	1,994	(52)
Accrued expense and other liabilities	4,532	3,853
Deferred revenue	(2,815)	11,885
Net cash used in operating activities	(110,822)	(61,358)
Cash flows from investing activities:
Purchases of property and equipment	(3,825)	(3,146)
Purchases of marketable securities	(241,445)	(77,613)
Proceeds from maturities of marketable securities	192,657	20,000
Net cash used in investing activities	(52,613)	(60,759)
Cash flows from financing activities:
Repayment of loan payable, net	(17,144)
Proceeds from borrowings under loan agreement, net	32,457
Proceeds from issuance of common stock, net of offering costs	33,131	42,414
Proceeds from issuance of pre-funded warrants, net of offering costs	158,271	92,318
Issuance of common stock under employee stock purchase plan	333
Proceeds from exercise of stock options	1,717	711
Net cash provided by financing activities	208,765	135,443
Net increase in cash, cash equivalents and restricted cash	45,330	13,326
Cash, cash equivalents, and restricted cash - beginning of year	138,390	125,064
Cash, cash equivalents, and restricted cash - end of year	183,720	138,390
Summary of cash, cash equivalents and restricted cash reported within the consolidated balance sheets:
Cash and cash equivalents	178,689	133,359
Restricted cash	5,031	5,031
Total cash, cash equivalents, and restricted cash	183,720	138,390
Supplemental disclosure of cash flow information:
Cash paid for interest	2,881	3,002
Supplemental disclosure of non-cash investing and financing activities:
Debt issuance costs not yet paid	400
Financing costs not yet paid	200
Lease liability arising from obtaining right-of-use asset	6,133	6,214
Purchase of property and equipment in accounts payable and accrued liabilities	84	$ 301
Issuance of common stock upon note conversion	$ 14,750