Statements of Stockholders' Deficit - USD ($) $ in Thousands	Total	Underwritten Public Offering	Common Stock	Common Stock Underwritten Public Offering	Additional Paid-in Capital	Additional Paid-in Capital Underwritten Public Offering	Accumulated Deficit
Beginning balance at Dec. 31, 2023	$ (72,759)		$ 5		$ 855,921		$ (928,685)
Beginning balance, shares at Dec. 31, 2023			57,970,044
Beginning balance, shares at Dec. 31, 2023	19
401(k) matching contribution	$ 3,683				3,683
401(k) matching contribution, shares	383,589		383,589
Vesting of restricted shares, shares			965,681
Stock-based compensation	$ 24,047				24,047
ESPP shares issued	2,401				2,401
ESPP shares issued, shares			375,381
Issuance of common stock from exercises of stock options	1,599				1,599
Issuance of common stock from exercises of stock options, shares			127,891
Issuance of common stock and pre-funded warrants in connection with the underwritten public offering, net		$ 121,775		$ 1		$ 121,774
Issuance of common stock and pre-funded warrants in connection with the underwritten public offering, net, shares				8,695,652
Net loss	(334,326)						(334,326)
Ending balance at Dec. 31, 2024	$ (253,580)		$ 6		1,009,425		(1,263,011)
Ending balance, shares at Dec. 31, 2024	68,518,238		68,518,238
Ending balance, shares at Dec. 31, 2024	19
401(k) matching contribution	$ 5,258				5,258
401(k) matching contribution, shares	616,377		616,377
Vesting of restricted stock units and performance stock units, net of employee tax obligations	$ (1,926)				(1,926)
Vesting of restricted stock units and performance stock units, net of employee tax obligations, shares			1,615,577
Stock-based compensation	28,719				28,719
ESPP shares issued	2,969				2,969
ESPP shares issued, shares			505,293
Issuance of common stock from exercises of stock options	1,638				1,638
Issuance of common stock from exercises of stock options, shares			163,540
Net loss	(221,247)						(221,247)
Ending balance at Dec. 31, 2025	$ (438,169)		$ 6		$ 1,046,083		$ (1,484,258)
Ending balance, shares at Dec. 31, 2025	71,419,025		71,419,025
Ending balance, shares at Dec. 31, 2025	19