X0206 3 2022-01-13 0 0001805087 GELESIS HOLDINGS, INC. NYSE: GLS 0001782999 PureTech Health plc 6 TIDE STREET, SUITE 400 BOSTON MA 02210 0 0 1 0 0001727395 PureTech Health LLC 6 TIDE STREET, SUITE 400 BOSTON MA 02210 0 0 1 0 Common Stock 16727582 I See footnote Stock Option (Right to Buy) 4.05 2027-06-15 Common Stock 77760 I See footnote Stock Option (Right to Buy) 4.05 2028-07-17 Common Stock 77760 I See footnote Stock Warrant 0.02 2023-08-16 Common Stock 216208 I See footnote Earnout Shares Common Stock 4526622 I See footnote PureTech Health LLC directly holds all of the securities reported in this Form 3. PureTech Health plc is the parent company of PureTech Health LLC, and has the power to direct the voting and disposition of securities held by PureTech Health LLC. The stock option is currently vested and exercisable. The stock option is currently vested and exercisable. The warrant is currently exercisable. On January 13, 2022, the reporting person received the right to acquire certain shares of the Issuer's Common Stock (the "Earnout Shares") pursuant to the Business Combination Agreement ("BCA") dated as of July 19, 2021, as amended on November 8, 2021, by and among Capstar Special Purpose Acquisition Corp., CPSR Merger Sub and Gelesis, Inc. ("Private Gelesis"). The Earnout Shares shall vest and be released upon the satisfaction of certain share price vesting conditions prior to January 13, 2027, as set forth in the BCA. /s/ Daphne Zohar 2022-01-21