144 0001782815 XXXXXXXX LIVE 0001447362 CASTLE BIOSCIENCES INC 001-38984 505 S. Friendswood Drive, Suite 401 Friendstown TX 77546 8667889007 FRANKLIN STOKES Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

5388 187179.12 29188659 11/11/2025 NASDAQ Common 08/08/2025 Performance Stock Units Issuer N 5388 08/08/2025 N/A Y Sales that were executed on November 11, 2025 are being reported on this Form 144 filed on November 12, 2025 given the EDGAR system was not accepting filings on November 11, 2025 in observance of the federal holiday. 11/11/2025 08/12/2025 /s/ Franklin Stokes