The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106   230,899 50,971 SH   DFND 1,2 50,971 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   1,904,174 102,984 SH   DFND 1,2 102,984 0 0
AEROVATE THERAPEUTICS INC COM 008064107   1,417,468 47,936 SH   DFND 1,2 47,936 0 0
AFFIMED N V ORDINARY SHS NEW N01045207   197,409 37,247 SH   DFND 1,2 37,247 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   10,462,582 263,940 SH   DFND 1,2 263,940 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   467,743 41,950 SH   DFND 1,2 41,950 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   2,055,912 13,600 SH   DFND 1,2 13,600 0 0
ATHIRA PHARMA INC COM 04746L104   493,200 180,000 SH   DFND 1,2 180,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102   3,600,411 23,022 SH   DFND 1,2 23,022 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   187,183 36,847 SH   DFND 1,2 36,847 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   944,582 10,815 SH   DFND 1,2 10,815 0 0
BIOMEA FUSION INC COM 09077A106   598,000 40,000 SH   DFND 1,2 40,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   1,633,733 1,166,952 SH   DFND 1,2 1,166,952 0 0
CABALETTA BIO INC COM 12674W109   804,379 47,150 SH   DFND 1,2 47,150 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101   277,879 370,950 SH   DFND 1,2 370,950 0 0
ENTRADA THERAPEUTICS INC COM 29384C108   695,492 49,082 SH   DFND 1,2 49,082 0 0
EXELIXIS INC COM 30161Q104   1,523,466 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102   4,918,582 859,892 SH   DFND 1,2 859,892 0 0
FIBROGEN INC COM 31572Q808   145,949 62,106 SH   DFND 1,2 62,106 0 0
GALERA THERAPEUTICS INC COM 36338D108   85,851 613,223 SH   DFND 1,2 613,223 0 0
GERON CORP COM 374163103   4,371,015 1,324,550 SH   DFND 1,2 1,324,550 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   12,379,771 368,665 SH   DFND 1,2 368,665 0 0
ILLUMINA INC COM 452327109   16,367,995 119,196 SH   DFND 1,2 119,196 0 0
IMMATICS N.V SHS N44445109   165,007 15,700 SH   DFND 1,2 15,700 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   438,750 6,750 SH   DFND 1,2 6,750 0 0
INCYTE CORP COM 45337C102   4,217,033 74,022 SH   DFND 1,2 74,022 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   2,600,625 219,277 SH   DFND 1,2 219,277 0 0
KODIAK SCIENCES INC COM 50015M109   167,910 31,922 SH   DFND 1,2 31,922 0 0
KYMERA THERAPEUTICS INC COM 501575104   437,175 10,875 SH   DFND 1,2 10,875 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103   2,554,308 118,255 SH   DFND 1,2 118,255 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   1,517,321 5,682 SH   DFND 1,2 5,682 0 0
MERUS N V COM N5749R100   4,030,905 89,516 SH   DFND 1,2 89,516 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   2,414,032 96,100 SH   DFND 1,2 96,100 0 0
NEUMORA THERAPEUTICS INC. COM 640979100   870,581 63,315 SH   DFND 1,2 63,315 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   5,258,355 436,378 SH   DFND 1,2 436,378 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   1,029,330 274,488 SH   DFND 1,2 274,488 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100   1,535,046 493,584 SH   DFND 1,2 493,584 0 0
REPLIMUNE GROUP INC COM 76029N106   1,674,352 204,939 SH   DFND 1,2 204,939 0 0
REVOLUTION MEDICINES INC COM 76155X100   235,279 7,300 SH   DFND 1,2 7,300 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   2,128,370 49,120 SH   DFND 1,2 49,120 0 0
ROIVANT SCIENCES LTD SHS G76279101   342,234 32,470 SH   DFND 1,2 32,470 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   366,689 7,450 SH   DFND 1,2 7,450 0 0
STANDARD BIOTOOLS INC COM 34385P108   5,103,415 1,883,179 SH   DFND 1,2 1,883,179 0 0
TOURMALINE BIO INC COM 89157D105   480,602 20,987 SH   DFND 1,2 20,987 0 0
XENON PHARMACEUTICALS INC COM 98420N105   4,592,574 106,680 SH   DFND 1,2 106,680 0 0