The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 586 40,273 SH   DFND 1,2 40,273 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 124 12,521 SH   DFND 1,2 12,521 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 491 29,984 SH   DFND 1,2 29,984 0 0
AFFIMED N V COM N01045108 167 81,172 SH   DFND 1,2 81,172 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 401 41,950 SH   DFND 1,2 41,950 0 0
ARGENX SE SPONSORED ADR 04016X101 392 1,110 SH   DFND 1,2 1,110 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 430 4,168 SH   DFND 1,2 4,168 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1,621 12,022 SH   DFND 1,2 12,022 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 518 6,115 SH   DFND 1,2 6,115 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 1,727 1,166,952 SH   DFND 1,2 1,166,952 0 0
CERUS CORP COM 157085101 51 14,172 SH   DFND 1,2 14,172 0 0
CHEMOCENTRYX INC COM 16383L106 1,851 35,830 SH   DFND 1,2 35,830 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 2,240 113,950 SH   DFND 1,2 113,950 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 657 370,950 SH   DFND 1,2 370,950 0 0
EARGO INC COM 270087109 3,031 2,886,724 SH   DFND 1,2 2,886,724 0 0
ENTRADA THERAPEUTICS INC COM 29384C108 2,232 141,593 SH   DFND 1,2 141,593 0 0
EXELIXIS INC COM 30161Q104 1,007 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102 7,004 853,050 SH   DFND 1,2 853,050 0 0
FIBROGEN INC COM 31572Q808 192 14,756 SH   DFND 1,2 14,756 0 0
GALERA THERAPEUTICS INC COM 36338D108 1,067 613,223 SH   DFND 1,2 613,223 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 22,631 510,978 SH   DFND 1,2 510,978 0 0
ILLUMINA INC COM 452327109 22,741 119,196 SH   DFND 1,2 119,196 0 0
INCYTE CORP COM 45337C102 2,292 34,391 SH   DFND 1,2 34,391 0 0
INVITAE CORP COM 46185L103 28 11,337 SH   DFND 1,2 11,337 0 0
IVERIC BIO INC COM 46583P102 2,009 111,984 SH   DFND 1,2 111,984 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,142 78,720 SH   DFND 1,2 78,720 0 0
KARUNA THERAPEUTICS INC COM 48576A100 54,352 241,639 SH   DFND 1,2 241,639 0 0
KODIAK SCIENCES INC COM 50015M109 152 19,622 SH   DFND 1,2 19,622 0 0
OTONOMY INC COM 68906L105 251 851,000 SH   DFND 1,2 851,000 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 841 144,840 SH   DFND 1,2 144,840 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100 4,729 493,584 SH   DFND 1,2 493,584 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 208 8,265 SH   DFND 1,2 8,265 0 0
RELMADA THERAPEUTICS INC COM 75955J402 209 5,642 SH   DFND 1,2 5,642 0 0
REPLIMUNE GROUP INC COM 76029N106 2,680 155,199 SH   DFND 1,2 155,199 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 1,067 177,900 SH   DFND 1,2 177,900 0 0
SEAGEN INC COM 81181C104 6,444 47,096 SH   DFND 1,2 47,096 0 0
SOMALOGIC INC CLASS A COM 83444K105 4,920 1,696,558 SH   DFND 1,2 1,696,558 0 0
SYNLOGIC INC COM 87166L100 65 68,634 SH   DFND 1,2 68,634 0 0
XENON PHARMACEUTICALS INC COM 98420N105 4,129 114,380 SH   DFND 1,2 114,380 0 0