X0306 4 2021-10-13 1 0001782223 Pyxis Oncology, Inc. PYXS 0001820027 Bayer World Investments B.V. ENERGIEWEG 1 MIJDRECHT P7 3641RT NETHERLANDS 0 0 0 1 Former 10% Owner 0001144145 BAYER AKTIENGESELLSCHAFT BAYERWERK, GEBAEUDE W11 KAISER-WILHELM-ALLEE 1 LEVERKUSEN 2M 51373 GERMANY 0 0 0 1 Former 10% Owner Common Stock 2021-10-13 4 C 0 2742338 A 2742338 D Series A Convertible Preferred Stock 2021-10-13 4 C 0 11362462 D Common Stock 1786831 0 D Series B Convertible Preferred Stock 2021-10-13 4 C 0 6076072 D Common Stock 955507 0 D Shares of Series A and Series B Convertible Preferred Stock converted into shares of the Issuer's common stock at the closing of the Issuer's initial public offering at a 6.359-for-1 conversion ratio for no additional consideration (except for the payment in cash in lieu of any fractional shares), and had no expiration date. The securities reported are held directly by Bayer World Investments B.V., a Dutch private limited company, which is an indirect, wholly owned subsidiary of Bayer Aktiengesellschaft, a German stock corporation. Accordingly, Bayer Aktiengesellschaft may be deemed to be an indirect beneficial owner of the shares beneficially owned directly by Bayer World Investments B.V. Bayer World Investments B.V., By: /s/ Patrick Lennaerts, Name: Patrick Lennaerts, Title: Managing Director 2021-10-15 Bayer Aktiengesellschaft, By: /s/ Christian Bank, Name: Christian Bank, Title: Head of Legal Mergers & Acquisitions 2021-10-15