X0306 4 2022-04-14 0 0001782223 Pyxis Oncology, Inc. PYXS 0001769457 Sullivan Lara C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 1 1 0 0 Chief Executive Officer Common Stock 2022-04-14 4 A 0 315273 0 A 1356636 D Represents restricted stock units ("RSUs") that vest on April 13, 2023, subject to the Reporting Person's continued employment through the vesting date. The Compensation Committee also approved a grant to the Reporting Person, effective January 3, 2023, of an additional 95,684 RSUs that vest on April 13, 2023, subject to the Reporting Person's continued employment through the grant and vesting dates. The Compensation Committee also approved a grant to the Reporting Person of $200,000 cash compensation that is payable in full on April 13, 2023, subject to the Reporting Person's continued employment through the payment date. /s/ Pamela Connealy, Attorney-in-Fact for Lara Sullivan 2022-04-15