SCHEDULE 13G/A 0001172661-23-000538 0001390202 XXXXXXXX LIVE 2 Common Stock, par value $0.001 per share 12/31/2025 0001782223 Pyxis Oncology, Inc. 747324101 321 Harrison Avenue Boston X1 02118 Rule 13d-1(b) Laurion Capital Management LP DE 0 4796479 0 4796479 4796479 N 7.72 IA PN Benjamin Alexander Smith X1 0 4796479 0 4796479 4796479 N 7.72 HC IN Janaka Sheehan Maduraperuma X0 0 4796479 0 4796479 4796479 N 7.72 HC IN Pyxis Oncology, Inc. 321 Harrison Avenue, Boston, UNITED STATES 02118 This statement is filed by: (i) Laurion Capital Management LP ("Laurion Capital"), a Delaware limited partnership, and the investment adviser to certain funds and accounts (the "Laurion Funds"), with respect to the shares of Common Stock (as defined in Item 2(d) below) directly held by the Laurion Funds; (ii) Mr. Benjamin Alexander Smith ("Mr. Smith"), the co-managing member of Laurion Capital GP LLC, the general partner of Laurion Capital, with respect to the shares of Common Stock directly held by the Laurion Funds. (iii) Mr. Janaka Sheehan Maduraperuma ("Mr. Maduraperuma"), the co-managing member of Laurion Capital GP LLC, the general partner of Laurion Capital, with respect to the shares of Common Stock directly held by the Laurion Funds. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the forgoing persons or any Reporting Person is, for thepurposes of Section 13 of the Act, the beneficial owner of the shares of Common Stock reported herein. The address of the business office of each of the Reporting Persons is 360 Madison Avenue, Suite 1900, New York, NY 10017. Laurion Capital is a Delaware limited partnership. Mr. Smith is a citizen of the United States. Mr. Maduraperuma is a citizen of the United Kingdom. N IA HC Laurion Capital Management LP - 4,796,479 Benjamin Alexander Smith - 4,796,479 Janaka Sheehan Maduraperuma - 4,796,479 7.72 Laurion Capital Management LP - 0 Benjamin Alexander Smith - 0 Janaka Sheehan Maduraperuma - 0 Laurion Capital Management LP - 4,796,479 Benjamin Alexander Smith - 4,796,479 Janaka Sheehan Maduraperuma - 4,796,479 Laurion Capital Management LP - 0 Benjamin Alexander Smith - 0 Janaka Sheehan Maduraperuma - 0 Laurion Capital Management LP - 4,796,479 Benjamin Alexander Smith - 4,796,479 Janaka Sheehan Maduraperuma - 4,796,479 Y N See Item 2. The Laurion Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares of Common Stock reported herein. Laurion Capital Master Fund Ltd., a Laurion Fund, has the right to receive or the power to direct the receipt of dividends or the proceeds from the sale of more than 5% of the shares of Common Stock. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Laurion Capital Management LP Jason Riesel 02/09/2026 Benjamin Alexander Smith Benjamin Alexander Smith 02/09/2026 Janaka Sheehan Maduraperuma Janaka Sheehan Maduraperuma 02/09/2026