X0508 4 2023-09-11 0 0001782223 Pyxis Oncology, Inc. PYXS 0001769457 Sullivan Lara C/O PYXIS ONCOLOGY, INC. 321 HARRISON AVENUE BOSTON MA 02118 1 1 0 0 President and CEO 0 Common Stock 2023-09-11 4 S 0 20000 2.2707 D 2605182 D Common Stock 2023-09-12 4 S 0 4917 2.2516 D 2600265 D Common Stock 2023-09-13 4 S 0 3000 2.2719 D 2597265 D Common Stock 2023-09-13 4 F 0 184742 2.13 D 2412523 D Reflects sales of common stock executed in multiple transactions. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected within the ranges set forth in footnotes 2 through 4 of this Form 4. The transaction was executed in multiple trades in prices ranging from $2.13 to $2.36. The transaction was executed in multiple trades in prices ranging from $2.21 to $2.30. The transaction was executed in multiple trades in prices ranging from $2.25 to $2.34. Represents shares withheld to cover taxes due upon the vesting of certain restricted stock units. /s/ Pamela Connealy, Attorney-in-Fact for Lara Sullivan 2023-09-13