X0306 4 2022-03-31 0001782223 Pyxis Oncology, Inc. PYXS 0001769457 Sullivan Lara C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true true Chief Executive Officer Common Stock 2022-03-31 4 A 0 742574 0 A 1041363 D Represents restricted stock units that vest over a four-year period, with 25% vesting on the first anniversary of the grant date, and the remaining 75% vesting in 12 substantially-equal quarterly installments thereafter, subject to the reporting person's continued employment through the applicable vesting date. /s/ Pamela Connealy, Attorney-in-Fact for Lara Sullivan 2022-04-04