X0306 4 2022-03-31 0001782223 Pyxis Oncology, Inc. PYXS 0001734389 Chin Mark C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true Common Stock 2022-03-31 4 A 0 66831 0 A 66831 D Common Stock 1745761 I See footnote Represents restricted stock units that vest 100% on the first anniversary of the grant date, subject to the reporting person's continued service through the applicable vesting date. These securities are held directly by Arix Bioscience Holdings Limited ("Arix"). The reporting person is one of four members of the Investment Committee of Arix and, in such capacity, may be deemed to share voting and dispositive power over the securities held by Arix. The reporting person disclaims beneficial ownership of such securities except to the extent of his respective pecuniary interests therein. /s/ Pamela Connealy, Attorney-in-Fact for Mark Chin 2022-04-04