X0306 4 2021-10-13 0001782223 Pyxis Oncology, Inc. PYXS 0001126556 FLAVIN JOHN L C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true Common Stock 2021-10-13 4 C 0 2388 A 171610 D Series B Convertible Preferred Stock 2021-10-13 4 C 0 15190 0 D Common Stock 2388 0 D These shares of Series B Convertible Preferred Stock converted automatically and for no additional consideration into Common Stock on a 6.359-for-1 basis upon completion of the Issuer's initial public offering (with fractional shares paid out in cash). The shares of Series B Convertible Preferred Stock had no expiration date. Includes 47,593 shares of restricted stock that are subject to vesting in six, substantially-equal quarterly installments beginning October 22, 2021, subject to the reporting person's continued service through the applicable vesting date. /s/ Pamela Connealy, Attorney-in-Fact for John Flavin 2021-10-15