X0306 4 2021-10-07 0001782223 Pyxis Oncology, Inc. PYXS 0001437909 Lewis-Hall Freda C C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true Stock Option (Right to buy) 16 2021-10-07 4 A 0 42191 0 A 2031-10-07 Common Stock 42191 42191 D These stock options vest as to 1/3 of the shares covered by the option on each annual general meeting of the Issuer's stockholders following the October 7, 2021 grant date, subject to the reporting person's continued service through the applicable vesting date. /s/ Pamela Connealy, Attorney-in-Fact for Freda Lewis-Hall 2021-10-12