X0306 4 2021-10-07 0001782223 Pyxis Oncology, Inc. PYXS 0001769457 Sullivan Lara C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true true Chief Executive Officer Stock Option (Right to buy) 16 2021-10-07 4 A 0 962289 0 A 2031-10-07 Common Stock 962289 962289 D Two-thirds of these stock options vest 25% on the first anniversary of the October 7, 2021 grant date, and then in 36 substantially-equal monthly installments thereafter, and one-third of these stock options vest in full on the fourth anniversary of the October 7, 2021 grant date, all subject to the reporting person's continued employment through the applicable vesting date. /s/ Pamela Connealy, Attorney-in-Fact for Lara Sullivan 2021-10-12