X0206 3 2021-10-07 0 0001782223 Pyxis Oncology, Inc. PYXS 0001769457 Sullivan Lara C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true true Chief Executive Officer Common Stock 298789 D Stock Option (Right to buy) 5.34 2031-03-30 Common Stock 990461 D Stock Option (Right to buy) 8.71 2031-09-14 Common Stock 61825 D Includes 161,844 shares of restricted stock that are subject to vesting in 26 substantially-equal monthly installments beginning November 2, 2021, subject to the reporting person's continued employment through the applicable vesting date. These stock options vest in 48 substantially-equal monthly installments beginning January 2, 2020, subject to the reporting person's continued employment through the applicable vesting date. These stock options vest 25% on the first anniversary of the closing of the Issuer's initial public offering, and then in 36 substantially-equal monthly installments thereafter, subject to the reporting person's continued employment through the applicable vesting date. Exhibit List: Exhibit 24 - Power of Attorney /s/ Pamela Connealy, Attorney-in-Fact for Lara Sullivan 2021-10-07