X0206 3 2021-10-07 0 0001782223 Pyxis Oncology, Inc. PYXS 0001633639 Cline Darren S C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 true Stock Option (Right to buy) 8.71 2031-08-18 Common Stock 15725 D These stock options vest in three, substantially-equal annual installments beginning on the first anniversary of the August 19, 2021 grant date, subject to the reporting person's continued service through the applicable vesting date. Exhibit List: Exhibit 24 - Power of Attorney /s/ Pamela Connealy, Attorney-in-Fact for Darren Cline 2021-10-07