SCHEDULE 13G 0001273087 XXXXXXXX LIVE Common Stock, par value $0.001 per share 06/27/2025 0001782223 Pyxis Oncology, Inc. 747324101 321 Harrison Avenue Boston MA 02118 Rule 13d-1(c) Millennium Management LLC DE 0.00 3542663.00 0.00 3542663.00 3542663.00 N 5.7 OO Millennium Group Management LLC DE 0.00 3542663.00 0.00 3542663.00 3542663.00 N 5.7 OO Israel A. Englander X1 0.00 3542663.00 0.00 3542663.00 3542663.00 N 5.7 IN Pyxis Oncology, Inc. 321 Harrison Avenue, Boston, Massachusetts 02118 Millennium Management LLC Millennium Group Management LLC Israel A. Englander Millennium Management LLC 399 Park Avenue New York, New York 10022 Millennium Group Management LLC 399 Park Avenue New York, New York 10022 Israel A. Englander c/o Millennium Management LLC 399 Park Avenue New York, New York 10022 Millennium Management LLC - Delaware Millennium Group Management LLC - Delaware Israel A. Englander - United States Y See response to Item 9 on each cover page. See response to Item 11 on each cover page. For each reporting person, the percent of the class reported herein as beneficially owned by such reporting person gives effect to shares deemed to be outstanding as provided in Rule 13d-3(d)(1)(i), if any, presuming that all those warrants to purchase shares of the class reported herein that are held or otherwise controlled by any reporting person are exercisable within sixty days of the date hereof. See response to Item 5 on each cover page. See response to Item 6 on each cover page. See response to Item 7 on each cover page. See response to Item 8 on each cover page. The securities disclosed herein as potentially beneficially owned by Millennium Management LLC, Millennium Group Management LLC and Mr. Englander are held by entities subject to voting control and investment discretion by Millennium Management LLC and/or other investment managers that may be controlled by Millennium Group Management LLC (the managing member of Millennium Management LLC) and Mr. Englander (the sole voting trustee of the managing member of Millennium Group Management LLC). The foregoing should not be construed in and of itself as an admission by Millennium Management LLC, Millennium Group Management LLC or Mr. Englander as to beneficial ownership of the securities held by such entities. Y Y Y N See Exhibit I Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit I: Joint Filing Agreement, dated as of June 30, 2025, by and among Millennium Management LLC, Millennium Group Management LLC and Israel A. Englander. Millennium Management LLC /s/ Gil Raviv 06/30/2025 Millennium Group Management LLC /s/ Gil Raviv 06/30/2025 Israel A. Englander /s/ Israel A. Englander 06/30/2025