X0306 4 2021-11-18 0 0001782223 Pyxis Oncology, Inc. PYXS 0001723092 Civik Thomas C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 1 0 0 0 Common Stock 2021-11-18 4 P 0 15700 12.74 A 15700 I By Civik Family Trust The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.47 to $13.10, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein. These shares are held directly by the Civik Family Trust, a revocable trust for which the Reporting Person and his spouse are the grantors. /s/ Pamela Connealy, Attorney-in-Fact for Thomas Civik 2021-11-19