Equity Incentive Plan - Stock option activity (Details) - 2019 Equity Incentive Plan - USD ($)	12 Months Ended
Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Number of options
Outstanding, beginning of period	596,466	480,274
Granted	147,340	123,062
Cancelled/Forfeited	(28,186)	(6,870)
Outstanding, end of period	715,620	596,466	480,274
Exercisable	516,242
Vested or expected to vest	715,620
Weighted average exercise price per share
Outstanding, beginning of period (in dollars per share)	$ 72.95	$ 89.49
Granted (in dollars per share)	5.79	5.68
Cancelled/Forfeited (in dollars per share)	5.36	21.8
Outstanding, end of period (in dollars per share)	61.79	$ 72.95	$ 89.49
Exercisable (in dollars per share)	83.26
Vested or expected to vest (in dollars per share)	$ 61.79
Weighted average remaining contractual term (in years)
Outstanding	6 years 1 month 6 days	6 years 2 months 12 days	6 years 9 months 18 days
Exercisable	5 years
Vested or expected to vest	6 years 1 month 6 days
Aggregate Intrinsic Value
Outstanding		$ 45,825
Additional Disclosures
Weighted average grant date fair value of options granted	$ 4.53	$ 4.35

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Gross number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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