Summary of significant accounting policies - Leases and Property and equipment (Details)	12 Months Ended
Dec. 31, 2022
Leases
Leases, election of practical expedients package	true
Minimum
Leases
Incremental borrowing rate (as a percent)	3.00%
Maximum
Leases
Incremental borrowing rate (as a percent)	4.30%
Computer equipment and software
Property and equipment
Useful life	3 years
Furniture and fixtures
Property and equipment
Useful life	7 years
Laboratory equipment and office furniture
Property and equipment
Useful life	7 years

Indicates (true false) whether practical expedients are elected for not reassessing whether any expired or existing contract is or contains lease, lease classification for expired or existing lease, and initial direct cost for any existing lease.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 842
-SubTopic 10
-Section 65
-Paragraph 1
-Subparagraph (j)
-URI https://asc.fasb.org/extlink&oid=128293352&loc=SL77916155-209984

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 842
-SubTopic 10
-Section 65
-Paragraph 1
-Subparagraph (f)
-URI https://asc.fasb.org/extlink&oid=128293352&loc=SL77916155-209984

Name:	us-gaap_LeasePracticalExpedientsPackage
Namespace Prefix:	us-gaap_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration