Property and equipment (Details) - USD ($)	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Property and equipment
Property and equipment, at cost	$ 140,877	$ 152,795
Less accumulated depreciation and amortization	(117,007)	(114,280)
Property and equipment-net	23,870	38,515
Depreciation expense	12,829	28,834	$ 11,126
Lab equipment
Property and equipment
Property and equipment, at cost	90,770	100,249
Furniture and fixtures
Property and equipment
Property and equipment, at cost	31,152	31,611
Computer equipment
Property and equipment
Property and equipment, at cost	$ 18,955	$ 20,935

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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