X0306 4 2021-07-01 0 0001580063 PROGENITY, INC. PROG 0001781561 Sarna Surbhi C/O PROGENITY, INC. 4330 LA JOLLA VILLAGE DRIVE, SUITE 200 SAN DIEGO CA 92122 1 0 0 0 Common Stock 2021-07-01 4 A 0 60137 0.00 A 60137 D Stock Option (Right to Buy) 3.41 2021-07-01 4 A 0 96456 0.00 A 2031-07-01 Common Stock 96456 96456 D Represents 60,137 restricted stock units, which vest in equal installments on the first, second, third and fourth anniversaries of July 1, 2021, subject to the Reporting Person's continued service to the Issuer. This option represents the right to purchase 96,456 shares of the Issuer's common stock, which vest in equal installments on the first, second, third and fourth anniversaries of July 1, 2021, subject to the Reporting Person's continued service to the Issuer. /s/ Will Pridgen, Attorney-in-Fact for Surbhi Sarna 2021-07-06