SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 4 Common Stock, par value $0.001 per share 04/29/2025 0001781174 Acrivon Therapeutics, Inc. 004890109 480 Arsenal Way Suite 100 Watertown MA 02472 Rule 13d-1(c) Perceptive Advisors LLC DE 0 3104139 0 3104139 3104139 N 9.9 IA Joseph Edelman X1 0 3104139 0 3104139 3104139 N 9.9 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 3104139 0 3104139 3104139 N 9.9 CO Acrivon Therapeutics, Inc. 480 Arsenal Way, Suite 100, Watertown, MA 02472 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.001 per share (the "Common Stock") of Acrivon Therapeutics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands Corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover page to this Schedule 13G. The ownership percentages reported are based on 31,354,984 shares of Common Stock outstanding as of April 21, 2025, as reported by the Issuer in its Definitive Proxy Statement on Schedule 14A filed with the Securities and Exchange Commission on April 25, 2025. The Master Fund directly holds 3,104,139 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own such shares. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own such shares. Perceptive Advisors: 9.9% Mr. Edelman: 9.9% Master Fund: 9.9 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 3,104,139 Mr. Edelman: 3,104,139 Master Fund: 3,104,139 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 3,104,139 Mr. Edelman: 3,104,139 Master Fund: 3,104,139 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/01/2025 Joseph Edelman /s/ Joseph Edelman 05/01/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 05/01/2025