X0306 4 2020-09-01 0 0001082038 DURECT CORP DRRX 0001781002 Bleichroeder LP 1345 AVENUE OF THE AMERICAS 47TH FLOOR NEW YORK NY 10105 0 0 1 0 Common Stock 2020-09-01 4 S 0 250000 1.68 D 26414656 I See footnote The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions. Prices ranged from $1.65 to $1.735 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. This form is filed by Bleichroeder LP. Bleichroeder LP serves as registered investment adviser to 21 April Fund, Ltd., 21 April Fund, LP and other managed accounts that directly hold these securities. Bleichroeder LP disclaims beneficial ownership of these securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that Bleichroeder LP is the beneficial owner of the securities for purposes of Section 16 or for any other purposes. 21 April Fund, Ltd. owns 16,036,514 shares and 21 April Fund, LP owns 4,718,700 shares respectively of these 26,414,656 shares reported in this form Michael M. Kellen, Chairman and CO-CEO of Bleichroeder LP 2020-09-02