SCHEDULE 13G/A 0001420506-25-000718 0001781002 XXXXXXXX LIVE 2 Common Shares 09/30/2025 0001817760 SmartKem, Inc. 83193D203 MANCHESTER TECHNOLOGY CENTER HEXAGON TOWER DELAUNAYS ROAD BLACKLEYMANCHESTER X0 M9 8GQ Rule 13d-1(b) Bleichroeder LP DE 231666 0 231666 0 231666 N 4.1 IA Bleichroeder Holdings LLC DE 231666 0 231666 0 231666 N 4.1 HC Andrew Gundlach X1 231666 0 231666 0 231666 N 4.1 HC SmartKem, Inc. MANCHESTER TECHNOLOGY CENTERHEXAGON TOWER, DELAUNAYS ROAD, BLACKLEYMANCHESTER, X0 M9 8GQ011 Bleichroeder Holdings LLC Bleichroeder LP Andrew Gundlach 1345 Avenue of the Americas, 47th Floor New York, NY 10105 Bleichroeder Holdings LLC and Bleichroeder LP: Delaware, USA Andrew Gundlach: United States N IA HC See cover page See cover page See cover page See cover page See cover page See cover page N Y N Bleichroeder LP ("Bleichroeder"), an investment adviser registered under Section 203 of the Investment Advisers Act of 1940, is deemed to be the beneficial owner of 231,666 shares, or 4.10% of the common stock believed to be outstanding as a result of acting as investment adviser to various clients. Clients of Bleichroeder have the right to receive and the ultimate power to direct the receipt of dividends from, or the proceeds of the sale of, such securities. N See Exhibit 99.1 Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Bleichroeder LP Andrew Gundlach 11/14/2025 Bleichroeder Holdings LLC Andrew Gundlach 11/14/2025 Andrew Gundlach Andrew Gundlach 11/14/2025