X0306 4 2022-03-04 0 0001478320 Adaptive Biotechnologies Corp ADPT 0001780664 RUBINSTEIN JULIE C/O ADAPTIVE BIOTECHNOLOGIES CORP. 1165 EASTLAKE AVENUE E SEATTLE WA 98109 0 1 0 0 President Common Stock 2022-03-04 4 A 0 185338 0.00 A 231126 D Common Stock 2022-03-07 4 S 0 4613 12.01 D 226513 D Stock Option (Right to Buy) 12.14 2022-03-04 4 A 0 463344 0.00 A 2032-03-04 Common Stock 463344 463344 D This transaction represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person. The options vest with respect to 1/4 of such shares on March 4, 2023, with 1/48 of such shares vesting thereafter at the end of each full month of continuous service until fully vested. /s/ Julie Rubinstein by Eric Billings, attorney-in-fact 2022-03-08