X0306 4 2022-06-28 0001429560 TREVENA INC TRVN 0001780448 Shin Barry C/O TREVENA, INC. 955 CHESTERBROOK BOULEVARD, SUITE 110 CHESTERBROOK PA 19087 0 1 0 0 SVP, CFO Common Stock 2022-06-28 4 S 0 31785 0.41 D 873056 D The transaction reported represents the sale of shares by the Reporting Person to satisfy tax withholding obligations in connection with the non-reportable vesting and settlement of restricted stock units. These are shares sold to satisfy tax withholding obigations in connection with the non-reportable vesting and settlement of restricted stock units granted on June 25, 2019. The price reported in column 4 is the weighted average price. These shares were sold in multiple transactions at prices ranging from $0.40 to $0.42 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Barry Shin 2022-06-29