X0306 4 2020-11-02 0 0001679363 Morphic Holding, Inc. MORF 0001779978 Tipirneni Praveen P. C/O MORPHIC HOLDING, INC. 35 GATEHOUSE DRIVE, A2 WALTHAM MA 02451 1 1 0 0 President and CEO Common Stock 2020-11-02 4 M 0 7777 4.32 A 11063 D Common Stock 2020-11-02 4 S 0 6845 25.5721 D 4218 D Common Stock 2020-11-02 4 S 0 932 26.1368 D 3286 D Common Stock 2020-11-02 4 S 0 6936 25.5989 D 669538 I By The Praveen P. Tipirneni Irrevocable Trust of 2019 Common Stock 2020-11-02 4 S 0 800 26.1447 D 668738 I By The Praveen P. Tipirneni Irrevocable Trust of 2019 Common Stock 2020-11-03 4 M 0 2605 4.32 A 5891 D Common Stock 2020-11-03 4 S 0 1700 25.8598 D 4191 D Common Stock 2020-11-03 4 S 0 905 26.2456 D 3286 D Common Stock 2020-11-03 4 S 0 2375 25.9633 D 666363 I By The Praveen P. Tipirneni Irrevocable Trust of 2019 Common Stock 2020-11-03 4 S 0 200 26.41 D 666163 I By The Praveen P. Tipirneni Irrevocable Trust of 2019 Common Stock 2020-11-04 4 M 0 6100 4.32 A 9386 D Common Stock 2020-11-04 4 S 0 6100 26.5783 D 3286 D Common Stock 2020-11-04 4 S 0 6238 26.5773 D 659925 I By The Praveen P. Tipirneni Irrevocable Trust of 2019 Stock Option (right to buy Common Stock) 4.32 2020-11-02 4 M 0 7777 0.00 D 2028-12-14 Common Stock 7777 455681 D Stock Option (right to buy Common Stock) 4.32 2020-11-03 4 M 0 2605 0.00 D 2028-12-14 Common Stock 2605 453076 D Stock Option (right to buy Common Stock) 4.32 2020-11-04 4 M 0 6100 0.00 D 2028-12-14 Common Stock 6100 446976 D Includes 2,500 shares and 786 shares of Common Stock acquired under the issuer's employee stock purchase plan on March 2, 2020 and August 31, 2020, respectively. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the holder. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 to $25.90 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.62 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 to $25.99 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. These securities are held of record by Sonali N. Shah, Trustee of The Praveen P. Tipirneni Irrevocable Trust of 2019. The reporting person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.58 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.13 to $26.12 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.17 to $26.41 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.38 to $26.26 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.21 to $27.00 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option vests as to 2.0833% of the total shares monthly, beginning January 14, 2019, with 100% of the total shares vested and exercisable on December 14, 2022, subject to the reporting person's provision of service to the issuer on each vesting date. /s/ Robert Farrell as attorney-in-fact for Praveen P. Tipirneni 2020-11-04