X0306 4 2022-08-31 0 0001347858 22nd Century Group, Inc. XXII 0001779921 ZERCHER MICHAEL 500 SENECA STREET, SUITE 507 BUFFALO NY 14204 0 1 0 0 President and COO Common Stock 2022-08-31 4 S 0 370789 1.35 D 904938 D Sales made pursuant to 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. The prices actually received ranged from $1.39 to $1.33. The reporting person has provided to the issuer, and will provide to any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range for all transactions reported in this Form 4 utilizing a weighted average price. /s/ John J. Wolfel, Attorney-in-Fact for Michael Zercher 2022-09-02