X0306 4/A 2022-03-21 2022-03-23 0 0001347858 22nd Century Group, Inc. XXII 0001779921 ZERCHER MICHAEL 500 SENECA STREET, SUITE 507 BUFFALO NY 14204 0 1 0 0 President and COO Common Stock 2022-03-21 4 A 0 210742 0 A 1275727 D Stock option (right to buy) 3.20 2031-03-19 Common Stock 85000 85000 D Stock option (right to buy) 1.07 2019-08-24 2026-08-24 Common Stock 250000 250000 D Stock option (right to buy) 1.07 2019-09-09 2026-08-24 Common Stock 300000 300000 D Stock option (right to buy) 1.07 2019-09-09 2026-08-24 Common Stock 100000 100000 D Stock option (right to buy) 1.39 2020-04-01 2027-05-24 Common Stock 68000 68000 D Stock option (right to buy) 2.76 2021-03-06 2028-03-06 Common Stock 77875 77875 D The restricted stock units vest 1/3 per year on March 21, 2023, 2024 and 2025, subject to continued service with the Company. This amendment is filed solely to correct the prior Form 4 to show that the restricted stock units were acquired by the reporting person. Options vest 1/3 per year on the anniversary of the date of grant, subject to continued service with the Company. /s/ John J. Wolfel, Attorney-in-Fact for Michael Zercher 2022-03-23