X0508 4 2024-01-20 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001779581 Scimeca Dario C/O PRECISION BIOSCIENCES, INC. 302 E PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 0 1 0 0 General Counsel and Secretary 1 Common Stock 2024-01-20 4 M 0 59345 A 172315 D Common Stock 2024-01-22 4 S 0 21287 0.36 D 151028 D Restricted Stock Units 2024-01-20 4 M 0 59345 0.00 D Common Stock 59345 118655 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs") on January 20, 2024. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock or, at the Issuer's option, an amount of cash equal to the fair market value of such share. The sales were effected pursuant to a Rule 10b5-1 plan adopted on July 14, 2023. The transaction was a sell-to-cover, with shares only sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The Reporting Person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees. On January 20, 2023 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2024, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. /s/ Dario Scimeca 2024-01-23