X0306 4 2020-02-28 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001779581 Scimeca Dario C/O PRECISION BIOSCIENCES, INC. 302 E PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 0 1 0 0 General Counsel and Secretary Common Stock 2020-02-28 5 A 0 E 2072 5.61 A 2072 D Common Stock 2020-08-31 5 A 0 E 3156 4.79 A 5228 D Common Stock 2021-02-26 5 A 0 E 2748 4.61 A 7976 D Common Stock 2021-08-31 5 A 0 E 548 10.68 A 8524 D Common Stock 2022-02-28 5 A 0 E 2049 3.61 A 10573 D Employee Stock Option (Right to Buy) 4.08 2022-03-03 4 A 0 131271 0.00 A 2032-03-02 Common Stock 131271 131271 D Restricted Stock Units 2022-03-03 4 A 0 82659 0.00 A Common Stock 82659 82659 D The option vests as to 25% of the underlying shares on March 3, 2023 and thereafter in twelve substantially equal installments at the end of each three-month period over the 36 months following such date, subject to the Reporting Person's continued service to the Company through the applicable vesting dates. The Reporting Person was granted restricted stock units ("RSUs"), which each represent a contingent right to receive one share of the Company's Common Stock. The RSUs shall vest in three equal annual installments on the anniversary of the grant date of such RSUs, subject to the Reporting Person's continued service to the Company through the applicable vesting dates. /s/ Dario Scimeca 2022-03-07