X0206 3 2019-07-17 0 0001680581 Fulcrum Therapeutics, Inc. FULC 0001778713 Cadavid Diego C/O FULCRUM THERAPEUTICS, INC. 26 LANDSDOWNE STREET CAMBRIDGE MA 02139 0 1 0 0 See Remarks Common Stock 71071 D Stock Option (right to buy) 4.83 2028-07-10 Common Stock 17857 D Stock Option (right to buy) 7.84 2029-01-21 Common Stock 80928 D The option was granted on July 11, 2018. The shares underlying the option are scheduled to vest in equal quarterly installments from July 16, 2018 through July 15, 2022. The option was granted on January 22, 2019. The shares underlying the option are scheduled to vest in equal quarterly installments from January 1, 2019 through December 31, 2022. Senior Vice President, Clinical Development Exhibit Index: 24.1 Power of Attorney /s/ Peter Thomson, as attorney-in-fact for Diego Cadavid 2019-07-17